Analysis on key points of smoke control and exhaust design for large-scale high-biocontainment production plants

China has gained rich experience in the design and construction of large-scale high-biocontainment production plants, and has gradually completed the pursuit and parallel running of developed countries, and is in a relatively leading state in some fields. However, due to the differences in the focus of fire protection, biosecurity and other fields, as well as the different requirements of animal and human products, there are huge differences in the design concept of smoke control and exhaust among different practitioners, which seriously affects the further improvement of the design level of high-biocontainment production plants. Through the combing and condensation of the key points of biosecurity and fire protection concerns in the relevant norms and standards of biosafety facilities (production workshops and laboratories) at home and abroad, combined with the analysis and summary of actual engineering cases, this paper systematically expounds the relevant requirements for the design of smoke control and exhaust in high-biocontainment production plants in China, discusses the design of key links such as fire partition division, smoke exhaust system, 70 ℃ fire valve and smoke exhaust fire valve setting, etc., and proposes targeted solutions, which provides suggestions for the preparation (revision) of relevant national norms and standards and references for the implementation of similar projects.